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A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered

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Descrição
Researchers from the group Mitochondrial regulation of cell death and steatohepatitis have revealed a new role for acid ceramidase (ACDase) in experimental models and in patients with NPC through the regulation of STARD1 and its impact on mitochondrial function.
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Lysosomal positioning diseases: beyond substrate storage
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Cells, Free Full-Text
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Adaptations of Energy Metabolism Associated with Increased Levels of Mitochondrial Cholesterol in Niemann-Pick Type C1-deficient Cells* - Journal of Biological Chemistry
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
From genes to hope
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Mechanism of StAR action. Following synthesis and an activating
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Niemann–Pick disease type C1 (NPC1) is associated with early-onset
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation - ScienceDirect
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Oxidative stress: a pathogenic mechanism for Niemann-Pick type C disease. - Abstract - Europe PMC
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