Temozolomide (NSC 362856), DNA Alkylator
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Descrição
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.
Human Methyl Purine DNA Glycosylase and DNA Polymerase β Expression Collectively Predict Sensitivity to Temozolomide
Biomedicines, Free Full-Text
Phase I and Pharmacokinetic Study of Temozolomide on a Daily-for-5-Days Schedule in Patients With Advanced Solid Malignancies
Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
Novel strategies of Raman imaging for monitoring the therapeutic benefit of temozolomide in glioblastoma - ScienceDirect
Temozolomide 85622-93-1 wiki
Frontiers An overview of glioblastoma multiforme and temozolomide resistance: can LC-MS-based proteomics reveal the fundamental mechanism of temozolomide resistance?
Temozolomide nano enabled medicine: promises made by the nanocarriers in glioblastoma therapy - ScienceDirect
Temozolomide (NSC 362856), DNA Alkylator
Selleck Chemical LLC Temozolomide 100mg 85622-93-1 CCRG81045, NSC 362856,TMZ
Phase 1 trial of temozolomide plus irinotecan plus O6‐benzylguanine in adults with recurrent malignant glioma - Quinn - 2009 - Cancer - Wiley Online Library
Human Methyl Purine DNA Glycosylase and DNA Polymerase β Expression Collectively Predict Sensitivity to Temozolomide
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